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KMID : 0624620230560060326
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BMB Reports
2023 Volume.56 No. 6 p.326 ~ p.334
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AcrAB?TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism
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Jang Soo-Jin
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Abstract
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Antibiotic resistance (AR) is a silent pandemic that kills millions worldwide. Although the development of new therapeutic agents against antibiotic resistance is in urgent demand, this has presented a great challenge, especially for Gram-negative bacteria that have inherent drug-resistance mediated by impermeable outer membranes and multidrug efflux pumps that actively extrude various drugs from the bacteria. For the last two decades, multidrug efflux pumps, including AcrAB?TolC, the most clinically important efflux pump in Gram-negative bacteria, have drawn great attention as strategic targets for re-sensitizing bacteria to the existing antibiotics. This article aims to provide a concise overview of the AcrAB?TolC operational mechanism, reviewing its architecture and substrate specificity, as well as the recent development of AcrAB?TolC inhibitors.
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KEYWORD
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AcrAB?TolC, Antibiotic resistance, Gram negative bacteria, Multidrug efflux pumps, RND family
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